Stage 1. Mesothelioma: The most common method of treatment for patients in stage 1 is surgical
removal either using pleurectomy/decortication or alternatively extrapleural pneumonectomy. It is
currently unknown whether chemotherapy or radiation therapy for stage 1 mesothelioma has any
value for the patient.
Localized Malignant Mesothelioma (Stage I)
- Standard treatment options:
- Solitary mesotheliomas:
- Surgical resection en bloc including contiguous structures to ensure wide disease-free margins. Sessile polypoid lesions should be treated with surgical resection to ensure maximal potential for cure.
- Intracavitary mesothelioma:
- Palliative surgery (i.e., pleurectomy and decortication) with or without postoperative radiation therapy.
- Extrapleural pneumonectomy.
- Palliative radiation therapy.
- Treatment options under clinical evaluation:
- Intracavitary chemotherapy following resection.
- Multimodality therapy.
- Other clinical trials.
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